Publications List

Ichihara K., Nakayama KI., Matsumoto A.
Identification of unannotated coding sequences and their physiological functions.
J. Biochem., 173: 237-42, 2023.

Wada R., Fujinuma S., Nakatsumi H., Matsumoto M., Nakayama KI.
Phosphorylation of PBX2, a novel downstream target of mTORC1, is determined by GSK3 and PP1.
J Biochem., 173: 129-38, 2023.

Lozano-Ureña A., Lázaro-Carot L., Jiménez-Villalba E., Montalbán-Loro R., Mateos-White I., Duart-Abadía P., Martínez-Gurrea I., Nakayama KI., Fariñas I, Kirstein M., Gil-Sanz C., Ferrón SR.
IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells.
Development., 150: dev200563, 2023.

Takahashi K., Amano H., Urano T., Li M., Oki M., Aoki K., Amizuka N., Nakayama KI., Nakayama K., Udagawa N., Higashi N.
p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms.
PLoS One, 18: e02768382023, 2023.

Oka T., Higa T., Sugahara O., Koga D., Nakayama S., Nakayama KI.
Ablation of p57+ quiescent cancer stem cells suppresses recurrence after chemotherapy of intestinal tumors.
Cancer Res., 83: 1393-409, 2023.

Shiraishi C., Matsumoto A., Ichihara K., Yamamoto T., Yokoyama T., Mizoo T., Hatano A., Matsumoto M., Tanaka Y., Matsuura-Suzuki E., Iwasaki S., Matsushima S., Tsutsui H., Nakayama KI.
RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function.
Nature Commun., 14: 2131, 2023.

Kito Y., Matsumoto A., Ichihara K., Shiraishi C., Tang R., Hatano A., Matsumoto M., Han P., Iwasaki S., Nakayama, KI.
The ASC-1 complex promotes translation initiation by scanning ribosomes.
EMBO J., 42: e112869, 2023.

Yumimoto K., Sugiyama S., Motomura S., Takahashi D., Nakayama KI.
Molecular evolution of Keap1 was essential for adaptation of vertebrates to terrestrial life.
Sci. Adv., 9: eadg2379, 2023.

Fujinuma S., Nakatsumi H., Shimizu H., Sugiyama S., Harada A., Goya T., Tanaka M., Kohjima M., Takahashi M., Izumi Y., Yagi M., Kang D., Kaneko M., Shigeta M., Bamba T., Ohkawa Y., Nakayama KI.
FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation.
Cell Rep., 42: 112530, 2023.

Kodama M., Toyokawa G., Sugahara O., Sugiyama S., Haratake N., Yamada Y., Wada R., Takamori S., Shimokawa M., Takenaka T., Tagawa T., Kittaka H., Tsuruda T., Tanaka K., Komatsu Y., Nakata K., Imado Y., Yamazaki K., Okamoto I., Oda Y., Takahashi M., Izumi Y., Bamba Y., Shimizu H., Yoshizumi T., Nakayama KI.
Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy.
Cell Rep., 42: 112899, 2023

Funasaki S., Hatano A., Nakatsumi H., Koga D., Sugahara O., Yumimoto K., Baba M., Matsumoto M., Nakayama KI.
A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection.
iScience, 26: 107552, 2023.

Sugiyama S., Yumimoto K., Fujinuma S., Nakayama KI.
Identification of effective CCR2 inhibitors for cancer therapy using humanized mice.
J. Biochem., [Epub ahead of print].

Maehara H., Kokaji T., Hatano A., Suzuki Y., Matsumoto M., Nakayama KI., Egami R., Tsuchiya T., Ozaki H., Morita K., Shirai M., Li D., Terakawa A., Uematsu S., Hironaka K. I., Ohno S., Kubota H., Araki H., Miura F., Ito T., Kuroda S.
DNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle.
Sci. Rep., 13: 19118, 2023.

Nomura M., Ohuchi M., Sakamoto Y., Kudo K., Yaku K., Soga T., Sugiura Y., Morita M., Hayashi K., Miyahara S., Sato T., Yamashita Y., Ito S., Kikuchi N., Sato I., Saito R., Yaegashi N., Fukuhara T., Yamada H., Shima H., Nakayama KI., Hirao A., Kawasaki K., Arai Y., Akamatsu S., Tanuma SI., Sato T., Nakagawa T., Tanuma N.
Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.
Nat. Commun.,14: 8095, 2023.

Chadani Y., Kanamori T., Niwa T., Ichihara K., Nakayama KI., Matsumoto A., Taguchi H.
Mechanistic dissection of premature translation termination induced by acidic residues-enriched nascent peptide.
Cell Rep.,  42: 113569, 2023.

Temma Y., Obi-Nagata K., Hoshiba Y., Miyake R., Katayama Y., Hagihara H., Suzuki N., Miyakawa T., Nakayama KI., Hayashi-Takagi A.
Effect of brain acidification on depression-related behaviors in diabetes mellitus.
Front. Psychiatry, 14: 1277097, 2023.

Sakaguchi C., Ichihara K., Nita A., Katayama Y., Nakayama KI.
Identification and characterization of novel proteins associated with CHD4.
Genes Cells, 27: 61-71, 2022.

Mise S., Matsumoto A., Shimada K., Hosaka T., Takahashi M., Ichihara K., Shimizu H., Shiraishi C., Saito D., Suyama M., Yasuda T., Ide T., Izumi Y., Bamba T., Kimura-Someya T., Shirouzu M., Miyata H., Ikawa M., Nakayama KI.
Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis.
Nature Commun., 13: 1071, 2022.

Higa T., Okita Y., Matsumoto A., Nakayama S., Oka T., Sugahara O., Koga D., Takeishi S., Nakatsumi H., Hosen N., Robine S., Taketo MM., Sato T., Nakayama KI.
Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium.
Nature Commun., 13: 1500, 2022.

Uematsu S., Ohno S., Tanaka KY., Hatano A., Kokaji T., Ito Y., Kubota H., Hironaka K. I., Suzuki Y., Matsumoto M., Nakayama KI., Hirayama A., Soga T., Kuroda S.
Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism.
iScience, 25: 103787, 2022.

Fujimoto M., Takii R., Matsumoto M., Okada M., Nakayama KI., Nakato R., Fujiki K., Shirahige K., Nakai A.
HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.
Nature Commun., 13: 4355, 2022.

Huda N., Khambu B., Liu G., Nakatsumi H., Yan S., Chen X., Ma M., Dong Z., Nakayama KI., Yin XM.
Senescence connects autophagy deficiency to inflammation and tumor progression in the liver.
Cell. Mol. Gastroenterol. Hepatol., 14: 333-55, 2022.

Shimizu H., Kodama M., Matsumoto M., Orba Y., Sasaki M., Sato A., Sawa H., Nakayama KI.
LIGHTHOUSE illuminates therapeutics for a variety of diseases including COVID-19
iScience, 25: 105314, 2022.

Nita A., Muto Y., Katayama Y., Matsumoto A., Nishiyama M., Nakayama KI.
The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells.
Cell Rep., 34: 108688, 2021.

Johmura Y., Yamanaka T., Omori S., Wang T-W., Sugiura Y., Matsumoto M., Suzuki N., Kumamoto S., Yamaguchi K., Hatakeyama S., Takami T., Yamaguchi R., Shimizu E., Ikeda K., Okahashi N., Mikawa R., Suematsu M., Arita M., Sugimoto M., Nakayama KI., Furukawa Y., Imoto S., Nakanishi M.
Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders.
Science, 371: 265-70, 2021.

Shimizu H., Nakayama KI.
A universal molecular prognostic score for gastrointestinal tumors.
NPJ Genom. Med., 6: 6, 2021.

Egami R., Kokaji T., Hatano A., Yugi K., Eto M., Morita K., Ohno S., Fujii M., Hironaka K., Uematsu S., Terakawa A., Bai Y., Pan Y., Tsuchiya T., Ozaki H., Inoue H., Uda S., Kubota H., Suzuki Y., Matsumoto M., Nakayama KI., Hirayama A., Soga T., Kuroda S.
Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle.
iScience, 24: 102217, 2021.

Kawamura A., Katayama Y., Kakegawa W., Ino D., Nishiyama M., Yuzaki M., Nakayama KI.
The autism-associated protein CHD8 is required for cerebellar development and motor function.
Cell Rep., 35: 108932, 2021.

Ichihara K., Matsumoto A., Nishida H., Kito Y., Shimizu H., Shichino Y., Iwasaki S., Imami K., Ishihama Y., Nakayama KI.
Combinatorial analysis of translation dynamics reveals eIF2 dependence of translation initiation at near-cognate codons.
Nucleic Acids Res., 49: 7298-317, 2021.

Nita A., Matsumoto A., Tang R., Shiraishi C., Ichihara K., Saito D., Suyama M., Yasuda T., Tsuji G., Furue M., Katayama B., Ozawa T., Murata T., Dainichi T., Kabashima K., Hatano A., Matsumoto M., Nakayama KI.
A ubiquitin-like protein encoded by the “noncoding” RNA TINCR promotes keratinocyte proliferation and wound healing.
PLOS Genet., 17: e1009686, 2021.

Matsuzaki F., Uda S., Yamauchi Y., Matsumoto M., Soga T., Maehara K., Ohkawa Y., Nakayama KI., Kuroda S., Kubota H.
An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver.
Cell Rep., 36: 109569, 2021.

Cherepanov SM., Gerasimenko M., Yuhi T., Furuhara K., Tsuji C., Yokoyama S., Nakayama KI., Nishiyama M., Higashida H.
Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism.
BMC Neurosci., 22: 32, 2021.

Maimaiti M., Sakamoto S., Sugiura M., Kanesaka M., Fujimoto A., Matsusaka K., Xu M., Ando K., Saito S., Wakai K., Imamura Y., Nakayama KI., Kanai Y., Kaneda A., Ikehara Y., Ikeda JI., Anzai N., Ichikawa T.
The heavy chain of 4F2 antigen promote prostate cancer progression via SKP-2.
Sci. Rep., 11: 11478, 2021.

Matsuhisa K., Saito A., Cai L., Kaneko M., Okamoto T., Sakaue F., Asada R., Urano F., Yanagida K., Okochi M., Kudo Y., Matsumoto M., Nakayama KI., Imaizumi K.
Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis.
FASEB J., 34: 865-80, 2020.

Oshikawa K., Matsumoto M., Kodama M., Shimizu H., Nakayama KI.
A fail-safe system to prevent oncogenesis by senescence is targeted by SV40 small T antigen.
Oncogene, 39: 2170-86, 2020.

Laukoter S., Beattie R., Pauler FM., Amberg N., Nakayama KI., Hippenmeyer S.
Imprinted cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development.
Nature Commun., 11: 195, 2020.

Masuda T., Noda Mi., Kogawa T., Kitagawa D., Hayashi N., Jomori T., Nakanishi Y., Nakayama KI., Ohno S., Mimori K.
Phase I dose-escalation trial to repurpose propagermanium, an oral CCL2 Inhibitor, in patients with breast cancer.
Cancer Sci., 111: 924-31, 2020.

Kodama M., Oshikawa K., Shimizu H., Yoshioka S., Takahashi M., Izumi Y., Bamba T., Tateishi C., Tomonaga T., Matsumoto M., Nakayama KI.
A shift in glutamine nitrogen metabolism contributes to malignant progression of cancer.
Nature Commun., 11: 1320, 2020.

Masuda T., Tsuruda Y., Matsumoto Y., Uchida H., Nakayama KI., Mimori K.
Drug repositioning in cancer: the current situation in Japan.
Cancer Sci., 111: 1039-46, 2020.

Wakabayashi Y., Tamura Y., Kouzaki K., Kikuchi N., Hiranuma K., Menuki K., Tajima T., Yamanaka Y., Sakai A., Nakayama KI., Kawamoto T., Kitagawa K., Nakazato K.
Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial ROS emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.
Am. J. Physiol.-Regul. Integr. Comp. Physiol., 318: R677-90, 2020.

Takahashi H., Ranjan A., Chen S., Suzuki H., Shibata M., Hirose T., Hirose H., Sasaki K., Abe R., Chen K., He Y., Zhang Y., Takigawa I., Tsukiyama T., Watanabe M., Fujii S., Iida M., Yamamoto J., Yamaguchi Y., Suzuki Y., Matsumoto M., Nakayama KI., Washburn MP., Saraf A., Florens L., Sato S., Tomomori-Sato C., Conaway RC., Conaway JW., Hatakeyama S.
The role of Mediator and Little Elongation Complex in transcription termination.
Nature Commun., 11: 1063, 2020.

Shimizu H., Nakayama KI.
Artificial intelligence in oncology.
Cancer Sci., 111: 1452-60, 2020.

Yumimoto K., Nakayama KI.
Recent insight into the role of FBXW7 as a tumor suppressor.
Semin. Cancer Biol., 67: 1-15, 2020.

Kawamura A., Katayama Y., Nishiyama M., Shoji H., Tokuoka K., Ueta Y., Miyata M., Isa T., Miyakawa T., Hayashi-Takagi A., Nakayama KI.
Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice.
Hum. Mol. Genet., 29: 1274-91, 2020.

Kito Y., Matsumoto M., Hatano A., Takami T., Oshikawa K., Matsumoto A., Nakayama KI.
Cell cycle–dependent localization of the proteasome to chromatin.
Sci. Rep., 10: 5801, 2020.

Nakagawa T, Nakayama K, Nakayama KI.
Knockout mouse models provide insight into the biological functions of CRL1 components.
Adv. Exp. Med. Biol., 1217: 147-71, 2020.

Nakagawa T., Hattori S., Nobuta R., Kimura R., Nakagawa M., Matsumoto M., Nagasawa Y., Funayama R., Miyakawa T., Inada T., Osumi N., Nakayama KI., Nakayama K.
The autism-related protein SETD5 controls neural cell proliferation through epigenetic regulation of rDNA expression.
iScience, 23: 101030, 2020.

Yamauchi Y., Nita A., Nishiyama M., Muto Y., Shimizu H., Nakatsumi H., Nakayama KI.
Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.
Genes Cells, 25: 427-38, 2020.

Yumimoto K., Yamauchi Y., Nakayama KI.
F-Box Proteins and Cancer.
Cancers, 12: 1249, 2020.

Tsukiyama T., Juqi Z., Kim J., Ogamino S., Shino Y., Masuda T., Merenda A., Matsumoto M., Fujioka Y., Hirose T., Terai S., Takahashi H., Ishitani T., Nakayama KI., Ohba Y., Koo B-K., Hatakeyama S.
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
Nature Commun., 11: 4586, 2020.

Shirane M., Wada M., Morita K., Hayashi N., Kunimatsu R., Matsumoto Y., Matsuzaki F., Nakatsumi H., Ohta K., Tamura Y., Nakayama KI.
Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation.
Nature Commun., 11: 4576, 2020.

Onoyama I., Nakayama S., Shimizu H., Nakayama KI.
Loss of Fbxw7 impairs development of and induces heterogeneous tumor formation in the mouse mammary gland.
Cancer Res., 80: 5515-30, 2020.

Shirane M., Shoji H., Hashimoto Y., Katagiri H., Kobayashi S., Manabe T., Miyakawa T., Nakayama KI.
Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning.
Mol. Brain, 13: 146, 2020.

Kawamura A., Abe Y., Seki F., Katayama Y., Nishiyama M., Takata N., Tanaka KF., Okano H., Nakayama KI.
Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain.
Mol. Brain, 13: 160, 2020.

Kokaji T., Hatano A., Ito Y., Yugi K., Eto M., Morita K., Ohno S., Fujii M., Hironaka KI., Egami R., Terakawa A., Tsuchiya T., Ozaki H., Inoue H., Uda S., Kubota H., Suzuki Y., Ikeda K., Arita M., Matsumoto M., Nakayama KI., Hirayama A., Soga T., Kuroda S.
Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity.
Sci. Signal., 13: eaaz1236, 2020.

Kodama M., Nakayama KI.
A second Warburg-like effect in cancer metabolism: The metabolic shift of glutamine-derived nitrogen: A shift in glutamine-derived nitrogen metabolism from glutaminolysis to de novo nucleotide biosynthesis contributes to malignant evolution of cancer.
Bioessays., 42: e2000169, 2020.

Kawata K., Yugi K., Hatano A., Kokaji T., Tomizawa Y., Fujii M., Uda S., Kubota H., Matsumoto M., Nakayama KI., Kuroda S.
Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data.
Genes Cells, 24: 82-93, 2019.

Shimizu H., Takeishi S., Nakatsumi H., Nakayama KI.
Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells.
JCI Insight, 4: pii-125138, 2019.

Muto Y., Moroishi T., Ichihara K., Nishiyama M., Shimizu H., Eguchi H., Moriya K., Koike K., Mimori K., Mori M., Katayama Y., Nakayama KI.
Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.
J. Exp. Med., 216: 950-65, 2019.

Sugiyama S., Yumimoto K., Inoue I., Nakayama KI.
SCF(Fbxw7) ubiquitylates KLF7 for degradation in a manner dependent on GSK-3–mediated phosphorylation.
Genes Cells, 24: 354-65, 2019.

Yumimoto K., Sugiyama S., Mimori K., Nakayama KI.
The potentials of CCL2-CCR2 blockers including propagermanium as anticancer agents.
Cancer Sci., 110: 2090-9, 2019.

Shimizu H., Nakayama KI.
A 23 gene–based molecular prognostic score precisely predicts overall survival of breast cancer patients.
EBioMedicine, 46: 150-9, 2019.

Honda H., Matsumoto M., Shijo M., Hamasaki H., Sadashima S., Suzuki SO., Aishima S., Kai K., Nakayama KI., Sasagasako N., Iwaki T.
Frequent detection of pituitary-derived PrPres in human prion diseases.
J. Neuropathol. Exp. Neurol., 78: 922-9, 2019.

Takii R., Fujimoto M., Matsumoto M., Srivastava P., Katiyar A., Nakayama KI., Nakai A.
HSF1-SGO2 complex promotes the heat shock response by recruiting RNA polymerase II.
EMBO J., 38: e102566, 2019.

Hagihara H., Catts VS., Katayama Y., Shoji H., Takagi T., Huang FL., Nakao A., Mori Y., Huang KP., Ishii S., Graef IA., Nakayama KI., Shannon Weickert C., Miyakawa T.
Decreased brain pH as a shared endophenotype of psychiatric disorders.
Neuropsychopharmacology, 43: 459-68, 2018.

Sakai E., Nakayama M., Oshima H., Kouyama Y., Niida A., Fujii S., Ochiai A., Nakayama KI., Mimori K., Suzuki Y., Hong CP., Ock CY., Kim SJ., Oshima M.
Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer.
Cancer Res., 78: 1334-46, 2018.

Mikamo M., Kitagawa K., Sakai S., Uchida C., Ohhata T., Nishimoto K., Niida H., Suzuki S., Nakayama KI., Inui N., Suda T., Kitagawa M.
Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis.
J. Mol. Sci., 19: pii: E474, 2018.

Nakayama S., Yumimoto K., Kawamura A., Nakayama KI.
Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCF^Fbxw7 in a manner dependent on the kinase GSK-3.
J. Biol. Chem., 293: 5705-14, 2018.

Morita M., Sato T., Nomura M., Sakamoto Y., Inoue Y., Tanaka R., Ito S., Kurosawa K., Yamaguchi K., Sugiura Y., Takizaki H., Yamashita Y., Katakura R., Sato I., Kawai M., Okada Y., Watanabe H., Kondoh G., Matsumoto S., Kishimoto A., Obata M., Matsumoto M., Fukuhara T., Motohashi H., Suematsu M., Komatsu M., Nakayama KI., Watanabe T., Soga T., Shima H., Maemondo M., Tanuma N.
Pkm1 confers metabolic advantages and promotes cell-autonomous tumor cell growth.
Cancer Cell, 33: 355-67, 2018.

Matsumoto M., Nakayama KI.
The promise of targeted proteomics for quantitative network biology.
Curr. Opin. Biotechnol., 54: 88-97, 2018.

Hashimoto Y., Shirane M., Nakayama KI.
TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation.
Genes Cells, 23: 418-34, 2018.

Kita Y., Katayama Y., Shiraishi T., Oka T., Sato T., Suyama M., Ohkawa Y., Miyata K., Oike Y., Shirane M., Nishiyama M., Nakayama KI.
The autism-related protein CHD8 cooperates with C/EBPβ to regulate adipogenesis.
Cell Rep., 23: 1988-2000, 2018.

Matsumoto A., Nakayama KI.
Hidden peptides encoded by putative noncoding RNAs.
Cell Struct. Funct., 43: 75-83, 2018.

Hosokawa H., Ungerbäck J., Wang X., Matsumoto M., Nakayama KI., Tanaka T., Rothenberg EV.
Transcription factor PU.1 represses and activates gene expression in early T cells by redirecting partner transcription factor binding.
Immunity, 48: 1119-34, 2018.

Nakatsumi H., Oka T., Higa T., Shirane M., Nakayama KI.
Nuclear-cytoplasmic shuttling protein PP2A^B56 contributes to mTORC1-dependent dephosphorylation of FOXK1.
Genes Cells, 23: 599-605, 2018.

Watanabe S., Fujiyama H., Takafuji T., Kayama K., Matsumoto M., Nakayama KI., Yoshida K., Sugimoto N., Fujita M.
Glutamate-rich WD40 repeat containing 1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.
J. Cell Sci., 131: jcs213009, 2018.

Kawata K., Hatano A., Yugi K., Sano T., Fujii M., Tomizawa Y., Kokaji T., Tanaka KY., Uda S., Suzuki Y., Matsumoto M., Nakayama KI., Saitoh K., Kato K., Ueno A., Ohishi M., Hirayama A., Soga T., Kuroda S.
Trans-omic analysis reveals selective responses to induced and basal insulin across signaling, transcriptional, and metabolic networks.
iScience, 7: 212-29, 2018.

Ito A., Jamal M., Ameno K., Tanaka N., Takakura A., Kawamoto T., Kitagawa K., Nakayama KI., Matsumoto A., Miki T., Kinoshita H.
Acetaldehyde administration induces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice.
Neurosci. Lett., 685: 50-4, 2018.

Hosokawa H., Romero-Wolf M., Yui MA., Ungerbäck J., Quiloan MJG., Matsumoto M., Nakayama KI., Tanaka T., Rothenberg EV.
Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16.
Nature Immunol., 19: 1427-40, 2018.

Sumitomo A., Saka A., Ueta K., Horike K., Hirai K., Gamo NJ., Hikida T., Nakayama KI., Sawa A., Sakurai T., Tomoda T.
Methylphenidate and guanfacine ameliorate ADHD-like phenotypes in Fez1-deficient mice.
Mol. Neuropsychiatry, 3: 223-33, 2018.

Hui K., Katayama Y., Nakayama KI., Nomura J., Sakurai T.
Characterizing vulnerable brain areas and circuits in mouse models of autism: Towards understanding pathogenesis and new therapeutic approaches.
Neurosci. Biobehav. Rev., [Epub ahead of print].

Abe Y., Honsho M., Itoh R., Kawaguchi R., Fujitani M., Fujiwara K., Hirokane M., Matsuzaki T., Nakayama K., Ohgi R., Marutani T., Nakayama KI., Yamashita T., Fujiki Y.
Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum.
Life Sci. Alliance, 1: e201800062, 2018.

Matsumoto J., Takada S., Kinugawa S., Furihata T., Nambu H., Kakutani N., Tsuda M., Fukushima A., Yokota T., Tanaka S., Takahashi H., Watanabe M., Hatakeyama S., Matsumoto M., Nakayama KI., Otsuka Y., Sabe H., Tsutsui H., Anzai T.
Brain-derived neurotrophic factor improves limited exercise capacity in mice with heart failure.
Circulation, 138: 2064-6, 2018.

Kayama K., Watanabe S., Takafuji T., Tsuji T., Hironaka K., Matsumoto M., Nakayama KI., Enari M., Kohno T., Shiraishi K., Kiyono T., Yoshida K., Sugimoto N., Fujita M.
GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.
EMBO Rep., 18: 123-37, 2017.

Matsumoto M., Matsuzaki F., Oshikawa K., Goshima N., Mori M., Kawamura Y., Ogawa K., Fukuda E., Nakatsumi H., Natsume T., Fukui K., Horimoto K., Nagashima T., Funayama R., Nakayama K. & Nakayama KI.
A large-scale targeted proteomics assay resource based on an in vitro human proteome.
Nature Methods, 14: 251-8, 2017.

Matsumoto A., Pasut A., Matsumoto M., Yamashita R., Fung J., Saghatelian A., Nakayama KI., Clohessy JG., Monteleone E., Pandolfi PP.
mTORC1 and muscle regeneration are regulated by the LINC00961 encoded SPAR polypeptide.
Nature, 541: 228-32, 2017.

Ohnishi T., Shirane M., Nakayama KI.
SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth.
Sci. Rep., 7: 41130, 2017.

Yamauchi T., Nishiyama M., Moroishi T., Kawamura A., Nakayama KI.
FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem-progenitor cells.
Mol. Cell. Biol., 37: e00470-16, 2017.

Yachie N., Robotic Biology Consortium (incl. Matsumoto M., Nakayama KI.), Natsume T.
Robotic crowd biology with Maholo LabDroids.
Nature Biotechnol., 35: 310-2, 2017.

Zhang S., Chen Q., Liu Q., Li Y., Sun X., Hong L., Ji S., Liu C., Geng J., Zhang W., Lu Z., Yin ZY., Zeng Y., Lin KH., Wu Q., Li Q., Nakayama K., Nakayama KI., Deng X., Johnson RL., Zhu L., Gao D., Chen L., Zhou D.
Hippo signaling suppresses cell ploidy and tumorigenesis through Skp2.
Cancer Cell, 31: 669-84, 2017.

Muto Y., Nishiyama M., Nita A., Moroishi T., Nakayama KI.
Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.
Nature Commun., 8: 16114, 2017.

Yaguchi H., Yabe I., Takahashi H., Watanabe M., Nomura T., Kano T., Matsumoto M., Nakayama KI., Watanabe M., Hatakeyama S.
Sez6l2 regulates phosphorylation of ADD and neuritogenesis.
Biochem. Biophys. Res. Commun., 494: 234-41, 2017.

Fukushima H., Shimizu K., Watahiki A., Hoshikawa S., Kosho T., Oba D., Sakano S., Arakaki M., Yamada A., Nagashima K., Okabe K., Fukumoto S., Jimi E., Bigas A., Nakayama KI., Nakayama K., Aoki Y., Wei W., Inuzuka H.
NOTCH2 Hajdu-Cheney mutations escape SCFFBW7-dependent proteolysis to promote osteoporosis.
Mol. Cell, 68: 645-58.e5., 2017.

Yonehara R., Nada S., Nakai T., Nakai M., Kitamura A., Ogawa A., Nakatsumi H., Nakayama KI., Li S., Standley DM., Yamashita E., Nakagawa A., Okada M.
Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nature Commun., 8: 1625, 2017.

Nakatsumi H., Matsumoto M., Nakayama KI.
Noncanonical pathway for regulation of CCL2 expression by an mTORC1-FOXK1 axis promotes recruitment of tumor-associated macrophages.
Cell Rep., 21: 2471-86, 2017.

Inoue D., Matsumoto M., Nagase R., Saika M., Fujino T., Nakayama KI., Kitamura T.
Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels.
Exp. Hematol., 44: 172-6, 2016.

Fujieda Y., Amengual O., Matsumoto M., Kuroki K., Takahashi H., Kono M., Kurita T., Otomo K., Kato M., Oku K., Bohgaki T., Horita T., Yasuda S., Maenaka K., Hatakeyama S., Nakayama KI., Atsumi T.
Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes.
Rheumatology, 55: 1117-26, 2016.

Nita A., Nishiyama M., Muto Y., Nakayama KI.
FBXL12 regulates T cell differentiation in a cell-autonomous manner.
Genes Cells, 5: 517-24, 2016.

Tanaka M., Shiota M., Nakao T., Uemura R., Nishi S., Ohkawa Y., Matsumoto M., Yamaguchi M., Osada-Oka M., Inagaki A., Takahashi K., Nakayama KI., Gi M., Izumi Y., Miura K., Iwao H.
Identification of low-abundance proteins in serum via the isolation of HSP72 complexes.
J Proteomics, 136: 214-21, 2016.

Hosokawa H., Tanaka T., Endo Y., Kato M., Shinoda K., Suzuki A., Motohashi S., Matsumoto M., Nakayama KI., Nakayama T.
Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells.
Nature Commun., 7: 11289, 2016.

Takeishi S., Nakayama KI.
To wake up cancer stem cells, or to let them sleep, that is the question.
Cancer Sci., 107: 875-81, 2016.

Duquesnes N., Callot C., Jeannot P., Daburon V., Nakayama KI., Manenti S., Davy A., Besson A.
p57Kip2 knock-in mouse reveals CDK-independent contribution in the development of Beckwith–Wiedemann syndrome.
J. Pathol., 239: 250-61, 2016.

Kitade S., Onoyama I., Kobayashi H., Yagi H., Yoshida S., Kato M., Tsunematsu R., Asanoma K., Sonoda K., Wake N., Hata K., Nakayama KI., Kato K.
FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors.
Cancer Sci., 107: 1399-405, 2016.

Katayama Y., Nishiyama M., Shoji H., Ohkawa Y., Kawamura A., Sato T., Suyama M., Takumi T., Miyakawa T., Nakayama KI.
CHD8 haploinsufficiency results in autistic-like phenotypes in mice.
Nature, 537: 675-9, 2016.

Hatano A., Matsumoto M., Nakayama KI.
Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling.
Genes Cells, 21: 1095-112, 2016.

Mizushima W., Takahashi H., Watanabe M., Kinugawa S., Matsushima S., Takada S., Yokota T., Furihata T., Matsumoto J., Tsuda M., Chiba I., Nagashima S., Yanagi S., Matsumoto M., Nakayama KI., Tsutsui H., Hatakeyama S.
The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.
J. Mol. Cell. Cardiol., 100: 43-53, 2016.

Lu W., Liu S., Li B., Xie Y., Adhiambo C., Yang Q., Nakayama KI., Matusik R., Chen Z.
SKP2 inactivation suppresses prostate tumorigenesis by enhancing JARID1B ubiquitination for H3K4me3 reduction.
Oncotarget, 6: 771-88, 2015.

Yumimoto K., Akiyoshi S., Ueo H., Sagara Y., Onoyama I., Ueo H., Ohno S., Mori M., Mimori K., Nakayama KI.
F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.
J. Clin. Invest., 125: 621-35, 2015.

Nakajima T., Kitagawa K., Ohhata T., Sakai S., Uchida C., Shibata K., Minegishi N., Yumimoto K., Nakayama KI., Masumoto K., Katou F., Niida H., Kitagawa M.
Regulation of GATA binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of Thr-176 in GATA binding protein 2.
J. Biol. Chem., 290: 10368-81, 2015.

Yumimoto K., Nakayama KI.
Fbxw7 suppresses cancer metastasis by inhibiting niche formation.
OncoImmunology, 4: e1022308, 2015.

Furutachi S., Miya H., Watanabe T., Kawai H., Yamasaki N., Harada Y., Imayoshi I., Nelson M., Nakayama KI., Hirabayashi Y., Gotoh Y.
Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells.
Nature Neurosci., 18: 657-65, 2015.

Hosokawa H., Kato M., Tohyama H., Tamaki Y., Endo Y., Kimura MY., Tumes DJ., Motohashi S., Matsumoto M., Nakayama KI., Tanaka T., Nakayama T.
Methylation of Gata3 at Arg261 regulates transactivation of the Il5 gene in T helper 2 cells.
J. Biol. Chem., 290: 13095-103, 2015.

Watanabe K., Yumimoto K., Nakayama KI.
FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1.
Genes Cells, 20: 667-74, 2015.

Kojima T., Yamada T., Akaishi R., Furuta I., Saitoh T., Nakabayashi K., Nakayama KI., Nakayama K., Akira S., Minakami H.
Role of the Atg9a gene in intrauterine growth and survival of fetal mice.
Reprod. Biol., 15: 131-8, 2015.

Nishiyama M., Nita A., Yumimoto K., Nakayama KI.
FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development.
Stem Cells, 33: 3327-40, 2015.

Tane S., Okayama H., Ikenishi A., Amemiya Y., Nakayama KI., Takeuchi T.
Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth.
Biochem. Biophys. Res. Commun., 466: 147-54, 2015.

Tsukada Y., Akiyama T., Nakayama KI.
Maternal TET3 is dispensable for embryonic development but is required for neonatal growth.
Sci. Rep., 5: 15876, 2015.

Matsunuma R., Niida H., Ohhata T., Kitagawa K., Sakai S., Uchida C., Shiotani B., Matsumoto M., Nakayama KI., Ogura H., Shiiya N., Kitagawa M.
UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation.
Mol. Cell. Biol., 36: 394-406, 2015.

Maehara K., Harada A., Sato Y., Matsumoto M., Nakayama KI., Kimura H., Ohkawa Y.
Tissue-specific expression of histone H3 variants diversified after species separation.
Epigenetics Chromatin, 8: 35, 2015.

Kotoshiba S., Gopinathan L., Pfeiffenberger E., Rahim A., Vardy LA., Nakayama K., Nakayama KI., Kaldis P.
p27 is regulated independently of Skp2 in the absence of Cdk2.
Biochim Biophys Acta., 1843: 436-45, 2014.

Tane S., Ikenishi A., Okayama H., Iwamoto N., Nakayama KI., Takeuchi T.
CDK inhibitors, p21Cip1 and p27Kip1, participate in cell cycle exit of mammalian cardiomyocytes.
Biochem. Biophys. Res. Commun., 443: 1105-9, 2014.

Lu Z., Bauzon F., Fu H., Cui J., Zhao H., Nakayama K., Nakayama KI., Zhu L.
Skp2 suppresses apoptosis in Rb1 deficient tumors by limiting E2F1 activity.
Nature Commun., 5: 3463, 2014.

Shirane M., Nakayama KI.
Mitochondria: FKBP38 and mitochondrial degradation.
Int. J. Biochem. Cell Biol., 51C: 19-22, 2014.

*Matsumoto A., *Takeishi S., Nakayama KI. (*Co-first authors)p57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling.
Blood, 123: 3429-39, 2014.

*Hashimoto Y., *Shirane M., Matsuzaki F., Saita S., Ohnishi T., Nakayama KI. (*Co-first authors)Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia.
J. Biol. Chem., 289: 12946-61., 2014.

Takeishi S., Nakayama KI.
Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells.
Br. J. Cancer, 111: 1054-9, 2014.

Moroishi T., Yamauchi T., Nishiyama M., Nakayama KI.
HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.
J. Biol. Chem., 289: 16430-41, 2014.

Kanatsu-Shinohara M., Onoyama I., Nakayama KI., Shinohara T.
SCF-type ubiquitin ligase Fbxw7 negatively regulates spermatogonial stem cell self-renewal.
Proc. Natl. Acad. Sci. U.S.A., 111: 8826-31, 2014.

Kitagawa K., Shibata K., Matsumoto A., Matsumoto M., Ohhata T., Nakayama KI., Niida H., Kitagawa M.
Fbw7 targets GATA3 through CDK2-dependent proteolysis and contributes to regulation of T-cell development.
Mol. Cell. Biol., 34: 2732-44, 2014.

Hashiguchi T., Oyamada A., Sakuraba K., Shimoda K., Nakayama KI., Iwamoto Y., Yoshikai Y., Yamada H.
Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against Listeria monocytogenes infection.
J. Immunol., 192: 4739-47, 2014.

Yamauchi T., Nishiyama M., Moroishi T., Yumimoto K., Nakayama KI.
MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-box RNA helicase DDX24.
Mol. Cell. Biol., 34: 3321-40, 2014.

Saita S., Shirane M., Ishitani T., Shimizu N., Nakayama KI.
Role of the ANKMY2-FKBP38 axis in regulation of the Sonic Hedgehog (Shh) signaling pathway
J. Biol. Chem., 289: 25639-54, 2014.

Adachi S., Homoto M., Tanaka R., Hioki Y., Murakami H., Suga H., Matsumoto M., Nakayama KI., Hatta T., Iemura SI., Natsume T.
ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.
Nucleic Acids Res., 42: 10037-49, 2014.

Yugi K., Kubota H., Toyoshima Y., Noguchi R., Kawata K., Komori Y., Uda S., Kunida K., Tomizawa Y., Funato Y., Miki H., Matsumoto M., Nakayama KI., Kashikura K., Endo K., Ikeda K., Soga T., Kuroda S.
Reconstruction of insulin signal flow from phosphoproteome and metabolome data.
Cell Rep., 8: 1171-83, 2014.

Saita S., Shirane M., Nakayama KI.
Selective escape of proteins from mitochondria during mitophagy.
Nature Commun., 4: 1410, 2013.

Takeishi S., Matsumoto A., Onoyama I., Naka K., Hirao A., Nakayama KI.
Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.
Cancer Cell, 23: 347-61, 2013.

Reavie L., Buckley SM., Loizou E., Takeishi S., Aranda-Orgilles B., Ndiaye-Lobry D., Abdel-Wahab O., Ibrahim S., Nakayama KI., Aifantis I.
Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.
Cancer Cell, 23: 362-75, 2013.

Furutachi S., Matsumoto A., Nakayama KI., Gotoh Y.
p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis.
EMBO J., 32: 970-81, 2013.

Hirano A., Yumimoto K., Tsunematsu R., Matsumoto M., Oyama M., Kozuka-Hata H., Nakagawa T., Lanjakornsiripan D., *Nakayama KI., *Fukada Y. (*Co-corresponding authors)FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes.
Cell, 152: 1106-18, 2013.

Yamamoto A., Takeya R., Matsumoto M., Nakayama KI., Sumimoto H.
Phosphorylation of Noxo1 at threonine-341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1.
FEBS J., 280: 5145-59, 2013.

Yumimoto K., Matsumoto M., Onoyama I., Imaizumi K., Nakayama KI.
F-box and WD repeat domain containing-7 (Fbxw7) targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.
J. Biol. Chem., 288: 28488-502, 2013.

Khor EC., Abel T., Tickner J., Chim SM., Wang C., Cheng T., Ng B., Ng PY., Teguh DA., Kenny J., Yang X., Chen H., Nakayama KI., Nakayama K., Pavlos N., Zheng MH., Xu J.
Loss of protein kinase C-delta protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorption.
PLoS One, 8: e70815, 2013.

Yumimoto K., Muneoka T., Tsuboi T., Nakayama KI.
Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF/Fbxl3) complex.
J. Biol. Chem., 288: 32766-76, 2013.

Ohnishi T., Shirane M., Hashimoto Y., Saita S., Nakayama KI.
Identification and characterization of a neuron-specific isoform of protrudin.
Genes Cells, 19: 97-111, 2013.

Zhao H., Bauzon F., Fu H., Lu Z., Cui J., Nakayama K., Nakayama KI., Locker J., Zhu L.
Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors.
Cancer Cell, 24: 645-59, 2013.

Chow C., Wong N., Pagano M., Lun SW., Nakayama KI., Nakayama K., Lo KW.
Regulation of APC/C(Cdc20) activity by RASSF1A-APC/C(Cdc20) circuitry.
Oncogene, 31: 1975-87, 2012.

Oshikawa K., Matsumoto M., Oyamada K., Nakayama KI.
Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
J. Proteome Res., 11: 796-807, 2012.

Nishiyama M., Skoultchi AI., Nakayama KI.
Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-beta-catenin signaling pathway.
Mol. Cell. Biol., 32: 501-12, 2012.

Kanie T., Onoyama I., Matsumoto A., Yamada M., Nakatsumi H., Tateishi Y., Yamamura S., Tsunematsu R., Matsumoto M., Nakayama KI.
Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation.
Mol. Cell. Biol., 32: 590-605, 2012.

Ellman MB., Kim J., An HS., Kroin JS., Li X., Chen D., Yan D., Buechter DD., Nakayama KI., Mochly-Rosen D., Liu B., Qvit N., Morganand S., Im HJ.
The pathophysiological role of the PKCdelta pathway in the intervertebral disc: In vitro, ex vivo and in vivo studies.
Arthritis Rheum., 64: 1950-9, 2012.

Bargagna-Mohan P., Paranthan RR., Hamza A., Zhan CG., Lee DM., Kim KB., Lau DL., Srinivasan C., Nakayama K., Nakayama KI., Herrmann H., Mohan R.
A corneal anti-fibrotic switch identified in genetic and pharmacological deficiency of vimentin.
J. Biol. Chem., 287: 989-1006, 2012.

Chan CH., Li CF., Yang WL., Gao Y., Lee SW., Feng Z., Huang HY., Tsai KKC., Flores LG., Shao Y., Hazle JD., Yu D., Wei W., Sarbassov D., Hung MC., Nakayama KI., Lin HK.
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, Herceptin sensitivity and tumorigenesis.
Cell, 149: 1098-111, 2012.

Liu N., Matsumoto M., Kitagawa K., Kotake Y., Suzuki S., Shirasawa S., Nakayama KI., Nakanishi M., Niida H., Kitagawa M.
Chk1 phosphorylates the tumor suppressor Mig-6, regulating the activation of EGF signaling.
EMBO J., 31: 2365-77, 2012.

Kita Y., Nishiyama M., Nakayama KI.
Identification of CHD7S as a novel splicing variant of CHD7 with functions similar and antagonistic to those of the full-length CHD7L.
Genes Cells, 17: 536-47, 2012.

Ishikawa Y., Hosogane M., Okuyama R., Aoyama S., Onoyama I., Nakayama KI., Nakayama K.
Opposing functions of Fbxw7 in keratinocyte growth-differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch.
Oncogene, 32: 1921-32, 2012.

Suzuki S., Fukasawa H., Misaki T., Togawa A., Ohashi N., Kitagawa K., Kotake Y., Niida H., Liu N., Nakayama K., Nakayama KI., Yamamoto T., Kitagawa M.
The amelioration of renal damage in Skp2-deficient mice is canceled by p27Kip1 deficiency in Skp2-/- p27-/- mice.
PLoS One, 7: e36249, 2012.

Yumimoto K., Matsumoto M., Oyamada K., Moroishi T., Nakayama KI.
Comprehensive identification of substrates for F-box proteins by differential proteomics analysis.
J. Proteome Res., 11: 3175–85, 2012.

Yokobori T., Mimori K., Iwatsuki M., Ishii H., Tanaka F., Sato T., Toh H., Sudo T., Iwaya T., Tanaka Y., Onoyama I., Kuwano H., Nakayama KI., Mori M.
Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma.
Int. J. Oncol., 41: 253-9, 2012.

Fukushima H., Matsumoto A., Inuzuka H., Zhai B., Lau AW., Wan L., Gao D., Shaik S., Yuan M., Gygi SP., Jimi E., Asara JM., Nakayama K., Nakayama KI., Wei W.
SCFFbw7 modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.
Cell Rep., 1: 434-43, 2012.

Grim JE., Knoblaugh SE., Guthrie KA., Hagar A., Swanger J., Hespelt J., Delrow JJ., Small T., Grady WM., Nakayama KI., Clurman BE.
Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer.
Mol. Cell. Biol., 32: 2160-7, 2012.

Hoshi H., Hao W., Fujita Y., Funayama A., Miyauchi Y., Hashimoto K., Miyamoto K., Iwasaki R., Sato Y., Kobayashi T., Miyamoto H., Yoshida S., Mori T., Kanagawa H., Katsuyama E., Fujie A., Kitagawa K., Nakayama KI., Kawamoto T., Sano M., Fukuda K., Ohsawa I., Ohta S., Morioka H., Matsumoto M., Chiba K., Toyama Y., Miyamoto T.
Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis.
J. Bone Miner. Res., 27: 2015-23, 2012.

Okita Y., Matsumoto A., Yumimoto K., Isoshita R., Nakayama KI.
Increased efficiency in the generation of induced pluripotent stem cells by Fbxw7 ablation.
Genes Cells, 17: 768-77, 2012.

Matsumoto A., Nakayama KI.
Role of key regulators of the cell cycle in maintenance of hematopoietic stem cells.
BBA – Gen. Subjects, 1830: 2335-44, 2012.

Cremasco V., Decker CE., Stumpo D., Blackshear PJ., Nakayama KI., Nakayama K., Lupu TS., Graham DB., Novack DV., Faccio R.
PKCδ deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts.
J. Bone Miner. Res., 27: 2452-63, 2012.

Tateishi Y., Matsumoto A., Kanie T., Hara E., Nakayama K., Nakayama KI.
Development of mice without Cip/Kip CDK inhibitors.
Biochem. Biophys. Res. Commun., 427: 285-92, 2012.

Okita Y., Nakayama KI.
UPS delivers pluripotency.
Cell Stem Cell, 11: 728-30, 2012.

Narumi R., Murakami T., Kuga T., Adachi J., Shiromizu T., Muraoka S., Kume H., Kodera Y., Matsumoto M., Nakayama KI., Miyamoto Y., Ishitobi M., Inaji H., Kato K., Tomonaga T.
A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples.
J. Proteome Res., 11: 5311-22, 2012.

Bohgaki M., Matsumoto M., Atsumi T., Kondo T., Yasuda S., Horita T., Nakayama KI., Okumura F., Hatakeyama S., Koike T.
Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin.
J. Cell. Mol. Med., 15: 141-51, 2011.

Onoyama I., Suzuki A., Matsumoto A., Tomita K., Katagiri H., Oike Y., Nakayama K., Nakayama KI.
Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.
J. Clin. Invest., 121: 342-54, 2011.

Inuzuka H., Shaik S., Onoyama I., Tseng A., Gao D., Maser R., Zhai B., Gutierrez A., Wan L., Lau A., Xiao Y., Christie A., Aster J., Settleman J., Kung AL., Gygi SP., Look T., Nakayama KI., DePinho RA., Wei W.
SCFFbw7 regulates cellular apoptosis by targeting the Mcl-1 oncoprotein for ubiquitination and destruction.
Nature, 471: 104-9, 2011.

Iriuchishima H., Takubo K., Matsuoka S., Onoyama I., Nakayama KI., Nojima Y., Suda T.
Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression.
Blood, 117: 2373-7, 2011.

Matsumoto A., Tateishi Y., Onoyama I., Okita Y., Nakayama K., Nakayama KI.
Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress.
Cancer Sci., 102: 749-55, 2011.

Katagiri K., Ueda Y., Tomiyama T., Yasuda K., Toda Y., Ikehara S., Nakayama KI., Kinashi T.
Deficiency of Rap1-GTP binding protein RAPL causes lymphoproliferative disorders through the mislocalization of cyclin-dependent kinase inhibitor p27kip1.
Immunity, 34: 24-38, 2011.

Tachiyama R., Ishikawa D., Matsumoto M., Nakayama KI., Yoshimori T., Yokota S., Himeno M., Tanaka Y., Fujita H.
Proteome of ubiquitin/MVB-Pathway: Possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation.
Genes Cells, 16: 448-66, 2011.

Lu C., Huang X., Zhang X., Roensch K., Cao Q., Nakayama KI., Blazar BR., Zeng Y., Zhou X.
MiR-221 and miR-155 regulate human dendritic cell development, apoptosis and IL-12 production through targeting of p27kip1, KPC1 and SOCS-1.
Blood, 117: 4293-303, 2011.

Sistrunk C., Macias E., Nakayama KI., Kim Y., Rodriguez-Puebla ML.
Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium.
Am. J. Pathol., 178: 2470-7, 2011.

Wu H., Pomeroy SL., Ferreira M., Teider N., Mariani J., Nakayama KI., Hatakeyama S., Tron VA., Saltibus LF., Spyracopoulos L., Leng RP.
UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53.
Nature Med., 17: 347-55, 2011.

Matsumoto A., Onoyama I., Sunabori T., Kageyama R., Okano H., Nakayama KI.
Fbxw7-dependent degradation of Notch is required for control of stemness and neuronal-glial differentiation in neural stem cells.
J. Biol. Chem., 286: 13754-64, 2011.

Yu Z., Ono C., Kim HB., Komatsu H., Tanabe Y., Sakae N., Nakayama KI., Matsuoka H., Sora I., Bunney WE., Tomita H.
Four mood stabilizers commonly induce FEZ1 expression in human astrocytes.
Bipolar Disord., 13: 486-99, 2011.

Matsumoto A., Takeishi S., Kanie T., Susaki E., Onoyama I., Tateishi Y., Nakayama K., Nakayama KI.
p57 is required for quiescence and maintenance of adult hematopoietic stem cells.
Cell Stem Cell, 9: 262-71, 2011.

Moroishi T., Nishiyama M., Takeda Y., Iwai K., Nakayama KI.
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
Cell Metab., 14: 339-51, 2011.

Matsumoto A., Susaki E., Onoyama I., Nakayama K., Hoshino M., Nakayama KI.
Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice.
Mol. Cell. Biol., 31: 4176-92, 2011.

Okumura F., Okumura AJ., Matsumoto M., Nakayama KI., Hatakeyama S.
TRIM8 regulates Nanog via Hsp90β-medicated nuclear translocation of STAT3 in embryonic stem cells.
Biochim. Biophys. Acta, 1813: 1784-92, 2011.

Fuster JJ., Gonzalez-Navarro H., Vinue A., Molina P., Andres-Manzano MJ., Nakayama KI., Nakayama K., Diez-Juan A., Bernad A., Rodriguez C., Martinez-Gonzalez J., Andres V.
Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism.
Arterioscler. Thromb. Vasc. Biol., 31: 2455-63, 2011.

Fotovati A., Abu-Ali S., Nakayama K., Nakayama KI.
Impaired ovarian development and reduced fertility in female mice deficient in Skp2.
J. Anat., 218: 668-77, 2011.

Zou P., Yoshihara H., Hosokawa K., Tai I., Shinmyozu K., Tsukahara F., Maru Y., Nakayama K., Nakayama KI., Suda T.
p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70.
Cell Stem Cell, 9: 247-61, 2011.

Inoue S., Matsushita T., Tomokiyo Y., Matsumoto M., Nakayama KI., Kinoshita T., Shimazaki K.
Functional analyses of the activation loop of phototropin2 in Arabidopsis.
Plant Physiol., 156: 117-28, 2011.

Matsuzaki F., Shirane M., Matsumoto M., Nakayama KI.
Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.
Mol. Biol. Cell, 22: 4602-20, 2011.

Wang H., Bauzon F., Ji P., Xu X., Sun D., Locker J., Sellers RS., Nakayama K., Nakayama KI., Cobrinik D., Zhu L.
Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1(+/-) mice.
Nature Genet., 42: 83-8, 2010.

Tada H., Okano HJ., Takagi H., Shibata S., Yao I., Matsumoto M., Saiga T., Nakayama KI., Kashima H., Takahashi T., Setou M., Okano H.
Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.
J. Biol. Chem., 285: 3840-9, 2010.

Masuda K., Ishikawa Y., Onoyama I., Unno M., de Alboran I. M., Nakayama KI., Nakayama K.
Complex regulation of cell cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts.
Oncogene, 29: 1798-809, 2010.

Iwatsuki M., Mimori K., Ishii H., Yokobori T., Takatsuno Y., Sato T., Toh H., Onoyama I., Nakayama KI., Baba H., Mori M.
Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: Clinical significance.
Int. J. Cancer, 126: 1828-37, 2010.

Tsukada Y., Ishitani T., Nakayama KI.
KDM7 is a dual demethylase for histone H3 lysines 9 and 27 and functions in brain development.
Genes Dev., 24: 432-7, 2010.

Tanaka S., Wakeyama H., Akiyama T., Takahashi K., Amano H., Nakayama KI., Nakamura K.
Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3.
Adv. Exp. Med. Biol., 658: 111-6, 2010.

Fujii M., Kanematsu T., Ishibashi H., Fukami K., Takenawa T., Nakayama KI., Moss SJ., Nabekura J., Hirata M.
Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of {gamma}-aminobutyric acid type A receptors.
J. Biol. Chem., 285: 4837-46, 2010.

Lin HK., Chen Z., Wang G., Nardella C., Lee SW., Chan CH., Yang WL., Wang J., Egia A., Nakayama KI., Cordon-Cardo C., Teruya-Feldstein J., Pandolfi PP.
Skp2 targeting suppresses tumourigenesis through p19Arf/p53-independent cellular senescence.
Nature, 464: 374-9, 2010.

Susaki E., Kaneko-Oshikawa C., Miyata K., Tabata M., Yamada T., Oike Y., Katagiri H., Nakayama KI.
Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity.
J. Biol. Chem., 285: 15538-47, 2010.

Chan CH., Lee SW., Li CF., Wang J., Yang WL., Wu1 CY., Wu J., Nakayama KI., Kang HY., Huang HY., Hung MC., Pandolfi PP., Lin HK.
Deciphering the transcription complex critical for RhoA gene expression and cancer metastasis.
Nature Cell Biol., 12: 457-67, 2010.

Old JB., Kratzat S., Hoellein A., Graf S., Nilsson JA., Nilsson L., Nakayama KI., Peschel C., Cleveland JL., Keller UB.
Skp2 Directs Myc-Mediated Suppression of p27Kip1 yet Has Modest Effects on Myc-Driven Lymphomagenesis.
Mol. Cancer Res., 8: 353-62, 2010.

Ma H., Byra EA., Yu L., Hu N., Kitagawa K., Nakayama KI., Kawamoto T., Ren J.
Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: Role of protein phosphatases.
J. Mol. Cell. Cardiol., 49: 322-9, 2010.

Okumura F., Matsunaga Y., Katayama Y., Nakayama KI., Hatakeyama S.
TRIM8 modulates STAT3 activity through negative regulation of PIAS3.
J. Cell Sci., 123: 2238-45, 2010.

Mizokami A., Tanaka H., IshibashiH., Umebayashi H., Fukami K., Takenawa T., Nakayama KI., Yokoyama T., Nabekura J., Kanematsu T., Hirata M.
GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice.
J. Neurochem., 114: 302-10, 2010.

Benirschke RC., Thompson JR., Nominè Y., Wasielewski E., Juranić N., Macura S, Hatakeyama S., Nakayama KI., Botuyan MV., Mer G.
Molecular basis for the association of human E4B U-box ubiquitin ligase with E2 conjugating enzymes UbcH5c and Ubc.
Structure, 18: 955-65, 2010.

Hatano A., Matsumoto M., Higashinakagawa T., Nakayama KI.
Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H3.
Biochem. Biophys. Res. Commun., 397: 93-99, 2010.

Gao Y., Gu C., Li S., Tokuyama T., Yokota N., Nakayama KI., Kitagawa M., Namba H.
p27 modulates tropism of mesenchymal stem cells toward brain tumors.
Exp. Ther. Med., in press.

Susaki E., Nakayama KI.
An animal model manifesting neurodegeneration and obesity.
Aging, 2: 453-6, 2010.

Tsukada Y., Nakayama KI.
In vitro histone demethylase assay.
Cold Spring Harb. Protoc., [Epub ahead of print].

Takeda H., Kawamura Y., Miura A., Mori M., Wakamatsu A., Yamamoto JI., Isogai T., Matsumoto M., Nakayama KI., Natsume T., Nomura N., Goshima N.
Comparative analysis of human src-family kinase substrate specificity in vitro.
J. Proteome Res., 9: 5982-93, 2010.

Hayakawa H., Fujikane A., Ito R., Matsumoto M., Nakayama KI., Sekiguchi M.
Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress.
Biochem. Biophys. Res. Commun., 403: 220-4, 2010.

Ohzono C., Etoh S., Matsumoto M., Nakayama KI., Hirota Y., Tanaka Y., Fujita H.
Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43.
Biol. Pharm. Bull., 33: 951-7, 2010.

Lu Y., Adegoke OAJ., Nepveu A., Nakayama KI., Bedard N., Cheng D., Peng J., Wing SS.
USP19 deubiquitinating enzyme supports cell proliferation 1 by stabilizing KPC1, a ubiquitin ligase for p27Kip1.
Mol. Cell. Biol., 29: 547-58, 2009.

Minhajuddin M., Bijli KM., Fazal F., Sassano A., Nakayama KI., Hay N., Platanias LC., Rahman A.
Protein kinase Cδ and PI 3-kinase/AKT activate mammalian target of rapamycin to modulate NF-κB activation and ICAM-1 expression in endothelial cells.
J. Biol. Chem., 284: 4052-61, 2009.

Endo A., Matsumoto M., Inada T., Yamamoto A., Nakayama KI., Kitamura N., Komada M.
Nucleolar structure and function regulated by a deubiquitinating enzyme USP36.
J. Cell Sci., 122: 678-86, 2009.

Nishiyama M., Oshikawa K., Tsukada Y., Nakagawa T., Iemura S., Natsume T., Fan Y., Kikuchi A., Skoultchi AI., Nakayama KI.
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.
Nature Cell Biol., 11: 172-82, 2009.

Mitra P., Ghule PN., van Der Deen M., Medina R., Xie RL., Holmes WF., Ye X., Nakayama KI., Harper JW., Stein JL., Stein GS., van Wijnen AJ.
CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P.
J. Cell. Physiol., 219: 438-48, 2009.

Tsukuba T., Yanagawa M., Okamoto K., Okamoto Y., Yasuda Y., Nakayama KI., Kadowaki T., Yamamoto K.
Impaired chemotaxis and cell adhesion due to decrease in wide range of cell-surface receptors in cathepsin E-deficient macrophages.
J. Biochem., 145: 565-73, 2009.

Susaki E., Nakayama K., Yamasaki L., Nakayama KI.
Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model.
Proc. Natl. Acad. Sci. U.S.A., 106: 5192-7, 2009.

Lin HK., Wang G., Chen Z., Teruya-Feldstein J., Liu Y., Chan CH., Yang WL., Erdjument-Bromage H., Nakayama KI., Nimer S., Tempst P., Pandolfi PP.
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.
Nature Cell Biol., 11: 420-32, 2009.

Saita S., Shirane M., Natume T., Iemura S., Nakayama KI.
Promotion of neurite extension by protrudin requires its interaction with VAMP-associated protein (VAP).
J. Biol. Chem., 284: 13766-77, 2009.

Matsumoto M., Oyamada K., Takahashi H., Sato T., Hatakeyama S., Nakayama KI.
Large-scale proteomic analysis of tyrosine phosphorylation induced by TCR or BCR activation reveals new signaling pathways.
Proteomics, 9: 3549-63, 2009.

Kimura T., Sakai M., Tabu K., Wang L., Tsunematsu R., Tsuda M., Sawa H., Nagashima K., Nishihara H., Hatakeyama S., Nakayama K., Ladanyi M., Tanaka S., Nakayama KI.
Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration.
Lab. Invest., 89: 645-56, 2009.

Yokobori T., Mimori K., Iwatsuki M., Ishii H., Onoyama I., Fukagawa T., Kuwano H., Nakayama KI., Mori M.
p53-altered FBXW7 expression determines poor prognosis in gastric cancer cases.
Cancer Res., 69: 3788-94, 2009.

Saiga T., Fukuda T., Matsumoto M., Tada H., Okano HO., Okano H., Nakayama KI.
Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.
Mol. Cell. Biol., 29: 3529-43, 2009.

Matsuda M., Tsutsumi K., Kanematsu T., Fukami K., Terada Y., Takenawa T., Nakayama KI., Hirata M.
Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels.
Biol. Reprod., 81: 681-9, 2009.

Zhang J., Hung AC., Ng PY., Nakayama KI., Hu Y., Li B., Porter AG., Dhakshinamoorthy S.
PKCdelta mediates Nrf2-dependent protection of neuronal cells from NO-induced apoptosis.
Biochem. Biophys. Res. Commun., 386: 750-6, 2009.

Jiang X., Austin PF., Niederhoff RA., Manson SR., Riehm JJ., Cook BL., Pengue G., Chitaley K., Nakayama K., Nakayama KI., Weintraub SJ.
Mechanoregulation of proliferation.
Mol. Cell. Biol., 29: 5104-14, 2009.

Susaki E., Nakayama KI.
Functional similarities and uniqueness of p27 and p57: insight from a knock-in mouse model.
Cell. Cycle., 8: 2497-501, 2009.

Ranchal I., González R., Bello RI., Ferrín G., Hidalgo AB., Linares CI., Aguilar-Melero P., González-Rubio S., Barrera P., Marchal T., Nakayama KI., de la Mata M., Muntané J.
The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity.
Int. J. Cancer, 125: 2270-80, 2009.

Oyamada A., Ikebe H., Itsumi M., Saiwai H., Okada S., Shimoda K., Iwakura Y., Nakayama KI., Iwamoto Y., Yoshikai Y., Yamada H.
Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.
J. Immunol., 183: 7539-46, 2009.

Wu YJ., Sala-Newby GB., Shu KT, Yeh HI., Nakayama KI., Nakayama K., Newby AC., Bond M.
S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo.
J. Vasc. Surg., 50: 1135-42, 2009.

Gallegos JR., Litersky J., Lee H., Sun Y., Nakayama KI., Nakayama K., Lu H.
SCF TrCP1 activates and ubiquitylates TAp63gamma.
J. Biol. Chem., 283: 66-75, 2008.

Shigematsu N., Fukuda T., Yamamoto T., Nishioku T., Yamaguchi T., Himeno M., Nakayama KI., Tsukuba T., Kadowaki T., Okamoto K., Higuchi S., Yamamoto K.
Association of cathepsin E deficiency with the increased territorial aggressive response of mice.
J. Neurochem., 105: 1394-404, 2008.

Mukai A., Mizuno E., Kobayashi K., Matsumoto M., Nakayama KI., Kitamura N., Komada M.
Dynamic regulation of ubiquitination and deubiquitination at the central spindle during cytokinesis.
J. Cell Sci., 15: 121(Pt8), 2008.

Inoue S., Kinoshita T., Matsumoto M., Nakayama KI., Doi M., Shimazaki K.
Blue light-induced autophosphorylation of phototropin is a primary step for signaling.
Proc. Natl. Acad. Sci. U.S.A., 105: 5626-31, 2008.

Matsuoka S., Oike Y., Onoyama I., Iwama A., Arai F., Takubo K., Mashimo Y., Oguro H., Nitta E., Ito K., Miyamoto K., Yoshiwara H., Hosokawa K., Nakamura Y., Gomei Y., Iwasaki H., Hayashi Y., Matsuzaki Y, Nakayama K., Ikeda Y., Hata A., Chiba S., Nakayama KI., Suda T.
Fbxw7 acts as a critical failsafe against premature loss of hematopoietic stem cells and development of T-ALL.
Genes Dev., 22: 986-91, 2008.

Shirane M., Ogawa M., Motoyama J., Nakayama KI.
Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse.
Genes Cells, 13: 635-51, 2008.

Matsumoto A., Kawamoto T., Mutoh F., Isse T., Oyama T., Kitagawa K., Nakayama KI., Ichiba M.
Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice.
Pharmacogenet. Genomics, 18: 847-52, 2008.

Tamamori-Adachi M., Takagi H., Hashimoto K., Goto K., Hidaka T., Koshimizu U., Yamada K., Goto I., Maejima Y., Isobe M., Nakayama KI., Inomata N., Shigetaka Kitajima S.
Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase.
Cardiovasc. Res., 80: 181-90, 2008.

Sakae N., Yamasaki N., Kitaichi K., Fukuda T., Yamada M., Yoshikawa H., Hiranita T., Tatsumi Y., Kira J., Yamamoto T., Miyakawa T., Nakayama KI.
Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants.
Hum. Mol. Genet., 17: 3191-203, 2008.

Kanei-Ishii C., Nomura T., Takagi T., Watanabe N., Nakayama KI., Ishii S.
Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for Nemo-like kinase (NLK)-induced degradation.
J. Biol. Chem., 283: 30540-8, 2008.

Onoyama I., Nakayama KI.
Fbxw7 in cell cycle exit and stem cell maintenance: insight from gene-targeted mice.
Cell Cycle, 7: 3307-13, 2008.

Miranda-Carboni GA., Krum SA., Yee K., Nava M., Deng QE., Pervin S., Collado-Hidalgo A., Galic Z., Zack JA., Nakayama K., Nakayama KI., Lane TF.
A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.
Genes Dev., 22: 3121-34, 2008.

Ohsaki K., Oishi K., Kozono Y., Nakayama K., Nakayama KI., Ishida N.
The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2.
J. Biochem., 144: 609-18, 2008.

Ishikawa Y., Onoyama I., Nakayama KI., Nakayama K.
Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7.
Oncogene, 27: 6164-74, 2008.

Agarwal A., Bumm TG., Corbin AS., O’Hare T., Loriaux M., VanDyke J., Willis SG., Deininger J., Nakayama KI., Druker BJ., Deininger MW.
Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease.
Blood, 112: 1960-70, 2008.

Chen Q., Xie W., Kuhn DJ., Voorhees PM., Lopez-Girona A., Mendy D., Corral LG., Krenitsky VP., Xu W., Moutouh-de Parseval L., Webb DR., Mercurio F., Nakayama KI., Nakayama K., Orlowski RZ.
Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy.
Blood, 111: 4690-9, 2008.

Song MS., Song SJ., Kim SJ., Nakayama K., Nakayama KI., Lim DS.
Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition.
Oncogene, 27: 3176-85, 2008.

Itoh Y., Masuyama N., Nakayama K., Nakayama KI., Gotoh Y.
The cdk inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex.
J. Biol. Chem., 282: 390-6, 2007.

Yanagawa M, Tsukuba T, Nishioku T, Okamoto Y, Okamoto K, Takii R, Terada Y, Nakayama KI, Kadowaki T, Yamamoto K.
Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages.
J. Biol. Chem., 282: 1851-62, 2007.

Sakai T., Sakaue H., Nakamura T., Okada M., Matsuki Y., Watanabe E., Hiramatsu R., Nakayama K., Nakayama KI., Kasuga M.
Skp2 controls adipocyte proliferation during the development of obesity.
J. Biol. Chem., 282: 2038-46, 2007.

Shukla A., Lounsbury KM., Barrett TF, Gell J., Rincon M., Butnor KJ., Taatjes DJ., Davis GS., Vacek P., Nakayama KI., Nakayama K., Steele C., Mossman BT.
Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-knockout mice.
Am. J. Pathol., 170: 140-51, 2007.

Uchida T., Iwashita N., Ohara-Imaizumi M., Ogihara T., Nagai S., Choi JB., Tamura Y., Tada N., Kawamori R., Nakayama KI., Nagamatsu S., Watada H.
PKC-delta plays non-redundant role in insulin secretion in pancreatic beta cell.
J. Biol. Chem., 282: 2707-2716, 2007.

Tu X., Joeng KS., Nakayama KI., Nakayama K., Rajagopal J., Carroll TJ., McMahon AP., Long F.
Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation.
Dev. Cell, 12: 113-27, 2007.

Moller C., Karlberg M., Abrink M., Nakayama KI., Motoyama N., Nilsson G.
Bcl-2 and Bcl-XL are indispensable for the late phase of mast cell development from mouse embryonic stem cells.
Exp. Hematol., 35: 385-93, 2007.

Nakagawa T., Shirane M., Iemura S., Natsume T., Nakayama KI.
Anchoring of the 26S proteasome to the organellar membrane by FKBP38.
Genes Cells, 12: 709-719, 2007.

Miyamoto K., Araki KY., Naka K., Arai F., Takubo K., Yamazaki S., Matsuoka S., Miyamoto T., Ito K., Ohmura M., Chen C., Hosokawa K., Nakauchi H., Nakayama K., Nakayama KI., Harada M., Motoyama N., Suda T., Hirao A.
Foxo3a is essential for maintenance of the hematopoietic stem cell pool.
Cell Stem Cell, 1: 101-12, 2007.

Matsuda T., Matsumoto A., Uchida M., Kanaly R., Misaki K., Shibutani S., Kawamoto T., Kitagawa K., Nakayama KI., Tomokuni K., Ichiba M.
Increased formation of hepatic N2-ethylidene-2′-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2 knockout mice treated with ethanol.
Carcinogenesis, 28: 2363-6, 2007.

Liu Z., Liu X., Nakayama KI., Nakayama K., Ye K.
Protein kinase C-delta phosphorylates Ebp1 and prevents its proteolytic degradation, enhancing cell survival.
J. Neurochem., 100: 1278-88, 2007.

Mizokami A., Kanematsu T., Ishibashi H., Yamaguchi T., Tanida I., Takenaka K., Nakayama KI., Fukami K., Takenawa T., Kominami E., Moss SJ., Yamamoto T., Nabekura J., Hirata M.
Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface.
J. Neurosci., 27: 1692-701, 2007.

Susaki E., Nakayama K., Nakayama KI.
Cyclin D2 translocates p27 out of the nucleus and promotes its degradation at the G0-G1 transition.
Mol. Cell. Biol., 27: 4626-40, 2007.

Suzuki S., Fukasawa H., Kitagawa K., Uchida C., Hattori T., Isobe T., Oda T., Misaki T., Ohashi N., Nakayama K., Nakayama KI., Hishida A., Yamamoto T. Kitagawa M.
Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice.
Am. J. Pathol., 171: 473-83, 2007.

Cooke PS., Holsberger DR., Cimafranca MA., Meling DD., Beals CM., Nakayama K., Nakayama KI., Kiyokawa H.
The F box protein Skp2 regulates adipose mass and adipocyte number in vivo.
Obesity, 15: 1400-8, 2007.

Wakeyama H., Akiyama T., Takahashi K., Amano H., Kadono Y., Nakamura M., Oshima Y., Itabe H., Nakayama KI., Nakayama K., Nakamura K., Tanaka S.
Negative feedback loop in Bim-caspase-3 axis regulating apoptosis and activity of osteoclasts.
J. Bone Miner. Res., 22: 1631-9, 2007.

Zhong L., Georgia S., Tschen S., Nakayama K., Nakayama KI., Bhushan A.
Skp2-mediated p27 degradation plays an essential role in the growth and adaptive expansion of pancreatic beta cells.
J. Clin. Invest., 117: 2869-76, 2007.

Ehre C., Zhu Y., Abdullah LH., Olsen JC., Nakayama KI., Nakayama K., Messing RO., Davis CW.
nPKC{epsilon}, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells.
Am. J. Physiol., Cell Physiol., 293: 1445-54, 2007.

Li W., Yamada H., Yajima T., Nakagawa R., Shimoda K., Nakayama KI., Yoshikai Y.
Tyk2 signaling in host environment plays an important role in contraction of antigen-specific CD8 T cells following a microbial infection.
J. Immunol., 178: 4482-8, 2007.

Onoyama I., Tsunematsu R., Matsumoto A., Kimura T., de Alboran IM., Nakayama K., Nakayama KI.
Conditional inactivation of Fbxw7 impairs cell cycle exit during T cell differentiation and results in lymphomatogenesis.
J. Exp. Med., 204: 2875-88, 2007.

Susaki E., Nakayama KI.
Multiple mechanisms for p27Kip1 translocation and degradation.
Cell Cycle, 6: 3015-20, 2007.

Kawakubo T., Okamoto K., Iwata J., Shin M., Okamoto Y., Yasukochi A., Nakayama KI., Kadowaki T., Tsukuba T., Yamamoto K.
Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface.
Cancer Res., 67: 10869-78, 2007.

Shirane M., Nakayama KI.
Protrudin induces neurite formation by directional membrane trafficking.
Science, 314: 818-21, 2006.

Kase S., Yoshida K., Harada T., Harada C., Namekata K., Suzuki Y., Ohgami K., Shiratori K., Nakayama KI., Ohno S.
Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment.
Graefes Arch. Clin. Exp. Ophthalmol., 244: 352-8, 2006.

Kase S., Yoshida K., Ohgami K., Shiratori K., Suzuki Y., Nakayama KI., Ohno S.
Expression of cdc2 and p27(KIP1) phosphorylation in mitotic cells of the human retinoblastoma.
Int. J. Mol. Med., 17: 465-8, 2006.

Kase S., Yoshida K., Ohgami K., Shiratori K., Nakayama KI., Ohno S.
Phosphorylation of p27(KIP1) in the mitotic cells of the corneal epithelium.
Curr. Eye Res., 31: 307-12, 2006.

Nishitani H., Sugimoto N., Roukos V., Nakanishi Y., Saijo M., Obuse C., Tsurimoto T., Nakayama KI., Nakayama K., Fujita M., Lygerou Z., Nishimoto T.
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
EMBO J., 25: 1126-36, 2006.

Humphries MJ., Limesand KH., Schneider JC., Nakayama KI., Anderson SM., Reyland ME.
Suppression of apoptosis in the PKCδ null mouse in vivo.
J. Biol. Chem., 281: 9728-37, 2006.

Yoshida K., Yamaguchi T., Shinagawa H., Taira N., Nakayama KI., Miki Y.
Protein kinase Cδ activates topoisomerase IIα to induce apoptotic cell death in response to DNA damage.
Mol. Cell. Biol., 26: 3414-31, 2006.

Parcellier A., Brunet M., Schmitt E., Col E., Didelot C., Hammann A., Nakayama K., Nakayama KI., Khochbin S., Solary E., Garrido C.
HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells.
FASEB J., 20: 1179-81, 2006.

Sugihara E., Kanai M., Saito S., Nitta T., Toyoshima H., Nakayama K., Nakayama KI., Fukasawa K. Schwab M., Saya H., Miwa M.
Suppression of centrosome amplification after DNA damage depends on p27 accumulation.
Cancer Res., 66: 4020-9, 2006.

Niki S., Oshikawa K., Mouri Y., Hirota F., Matsushima A., Yano M., Han H., Bando Y., Izumi K., Matsumoto M., Nakayama KI., Kuroda N., Matsumoto M.
Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice.
J. Clin. Invest., 116: 1292-1301, 2006.

Ryer EJ., Hom RP., Sakakibara K., Nakayama KI., Nakayama K., Faries PL., Liu B., Kent KC.
PKCdelta is necessary for Smad3 expression and transforming growth factorbeta-induced fibronectin synthesis in vascular smooth muscle cells.
Arterioscler. Thromb. Vasc. Biol., 26: 780-6, 2006.

Iwanaga R., Komori H., Ishida S., Okamura N., Nakayama K., Nakayama KI. Ohtani K.
Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners.
Oncogene, 25: 1786-98, 2006.

Nakayama KI., Nakayama K.
Ubiquitin ligases: cell-cycle control and cancer.
Nature Rev. Cancer, 6: 369-81, 2006.

Fotovati A., Nakayama K., Nakayama KI.
Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice.
Cell Div., 1: 4, 2006.

Fujii Y., Yada M., Nishiyama M., Kamura T., Takahashi H., Tsunematsu R., Susaki E., Nakagawa T., Matsumoto A., Nakayama KI.
Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation.
Cancer Sci., 97: 729-36, 2006.

Shimazu T., Komatsu Y., Nakayama KI., Fukazawa H., Horinouchi S., Yoshida M.
Regulation of SV40 large T antigen stability by reversible acetylation.
Oncogene, 25: 7391-400, 2006.

Kanematsu T., Yasunaga A., Mizoguchi Y., Kuratani A., Kittler JT., Jovanovic JN., Takenaka K., Nakayama KI., Fukami K., Takenawa T., Moss SJ., Nabekura J., Hirata M.
Modulation of GABA(a) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying BDNF-dependent regulation of GABAergic inhibition.
J. Biol. Chem., 281: 22180-9, 2006.

Tsunematsu R., Nishiyama M., Kotoshiba S., Saiga T., Kamura T., Nakayama KI.
Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development.
Mol. Cell. Biol., 26: 6157-69, 2006.

Nojima T., Hayashi K., Goitsuka R., Nakayama K., Nakayama KI., Kitamura D.
Double knockout mice show BASH and PKCd have different epistatic relationships in B cell maturation and CD40-mediated activation.
Immunol. Lett., 105: 48-54, 2006.

Hiramatsu Y., Kitagawa K., Suzuki T., Uchida C., Hattori T., Kikuchi H., Oda T., Hatakeyama S., Nakayama KI., Yamamoto T., Konno H., Kitagawa M.
Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination.
Cancer Res., 66: 8477-83, 2006.

Hara K., Nakayama KI., Nakayama K.
Geminin is essential for the development of preimplantation mouse embryos.
Genes Cells, 11: 1281-93, 2006.

Pula G., Schuh K., Nakayama K., Nakayama KI., Walter U., Poole AW.
PKCδ regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation.
Blood, 108: 4035-44, 2006.

Takahashi A., Ohtani N., Yamakoshi K., Iida S., Tahara H., Nakayama K., Nakayama KI., Ide T., Saya H., Hara E.
Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence through activating ROS/PKC-δ signalling pathway.
Nature Cell Biol., 8: 1291-7, 2006.

Matsumoto A., Onoyama I., Nakayama KI.
Expression of mouse Fbxw7 isoforms is regulated in a cell cycle- or p53-dependent manner.
Biochem. Biophys. Res. Commun., 350: 114-9, 2006.

Shukla A., Barrett TF., Nakayama KI., Nakayama K., Mossman BT., Lounsbury KM.
Transcriptional up-regulation of MMPs 12 and 13 by asbestos occurs via a PKC -dependent pathway in murine lung.
FASEB J., 20: 997-9, 2006.

Tsukuba T., Yamamoto S., Yanagawa M., Okamoto K., Okamoto Y., Nakayama KI., Kadowaki T., Yamamoto K.
Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors.
J. Biochem., 140: 57-66, 2006.

Gao Y., Kitagawa K., Hiramatsu Y., Kikuchi H., Isobe T., Shimada M., Uchida C., Hattori T., Oda T., Nakayama K., Nakayama KI. Tanaka T., Konno H. Kitagawa M.
Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis.
Cancer Res., 66: 11623-31, 2006.

Jackson D., Zheng Y., Lyo D., Shen Y., Nakayama K., Nakayama KI., Humphries MJ., Reyland ME., Foster DA.
Suppression of cell migration by protein kinase Cδ.
Oncogene, 24: 3067-72, 2005.

Harada K., Takeuchi H., Oike M., Matsuda M., Kanematsu T., Yagisawa H., Nakayama KI., Maeda K., Christophe E., Hirata M.
Role of PRIP-1, a novel Ins(1,4,5)P3 binding protein, in Ins(1,4,5)P3-mediated Ca2+ signaling.
J. Cell. Physiol., 202: 422-33, 2005.

Kotake Y., Nakayama K., Ishida N., Nakayama KI.
Role of serine-10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine-10 mutation.
J. Biol. Chem., 280: 1095-102, 2005.

Takahashi H., Hatakeyama S., Saitoh H., Nakayama KI.
Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein (PML).
J. Biol. Chem., 280: 5611-21, 2005.

Rodier G., Makris C., Coulombe P., Nakayama K., Nakayama KI., Meloche S.
p107 inhibits G1 phase progression by down-regulating expression of the F-box protein Skp2.
J. Cell Biol., 168: 55-66, 2005.

He CH., Waxman AB., Lee CG., Link H., Rabach ME., Ma B., Chen Q., Zhu Z., Zhong M., Nakayama K., Nakayama KI., Homer RJ., Elias JA.
Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury.
J. Clin. Invest., 115: 1039-48, 2005.

Matsumoto M., Hatakeyama S., Oyamada K., Oda Y., Nishimura T., Nakayama KI.
Large-scale analysis of the human ubiquitin-related proteome.
Proteomics, 5: 4145-51., 2005.

Uchida T., Nakamura T., Hashimoto N., Matsuda T., Kotani K., Sakaue H., Kido Y., Hayashi Y., Nakayama KI, White MF., Kasuga M.
Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice.
Nature Med., 11: 175-82, 2005.

Kase S., Nakayama KI., Nakayama K., Ikeda H., Harada T., Harada C., Ohgami K., Shiratori K., Ohno S., Yoshida K.
Phosphorylation of p27(KIP1) in the developing retina and retinoblastoma.
Int. J. Mol. Med., 16: 257-62, 2005.

Kotoshiba S., Kamura T., Hara T., Ishida N., Nakayama KI.
Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 Phase.
J. Biol. Chem., 280: 17694-700, 2005.

Kase S., Ikeda H., Harada T., Harada C., Imaki J., Ohgami K., Shiratori K., Nakayama KI., Nakayama K., Ohno S., Yoshida K.
Disappearance of p27(KIP1) and increase in proliferation of the lens cells after extraction of most of the fiber cells of the lens.
Curr. Eye Res., 30: 437-42, 2005.

Wang HQ., Nakaya Y., Du Z., Yamane T., Shirane M., Kudo T., Takeda M., Takebayashi K., Noda Y., Nakayama KI., Nishimura M.
Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2.
Hum. Mol. Genet., 14: 1889-902, 2005.

Jiang H., Chang FC., Ross AE., Lee J., Nakayama KI., Nakayama K, Desiderio S.
Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle.
Mol. Cell, 18: 699-709, 2005.

Hatakayama S., Watanabe M., Fujii Y., Nakayama KI.
Targeted destruction of c-Myc by an engineered ubiquitin ligase suppresses cell transformation and tumor formation.
Cancer Res., 65: 7874-9, 2005.

Pushkarsky T., Yurchenko V., Vanpouille C., Brichacek B., Vaisman I., Hatakeyama S., Nakayama KI., Sherry B., Bukrinsky MI.
Cell surface expression of CD147/emmprin is regulated by cyclophilin 60.
J. Biol. Chem., 280: 27866-71, 2005.

Hino S., Tanji C., Nakayama KI., Kikuchi A.
Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination.
Mol. Cell. Biol., 25: 9063-72, 2005.

Hara T., Kamura T., Kotoshiba S., Takahashi H., Fujiwara K., Onoyama I., Shirakawa M., Mizushima N., Nakayama KI.
Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle.
Mol. Cell. Biol., 25: 9292-303, 2005.

Chen Z., Foster MW., Zhang J., Mao L., Rockman HA., Kawamoto T., Kitagawa K., Nakayama KI., Hess DT., Stamler JS.
An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.
Proc. Natl. Acad. Sci. U.S.A., 102: 12159-64, 2005.

Kaneko-Oshikawa C., Nakagawa T., Yamada M., Yoshikawa H., Matsumoto M., Yada M., Hatakeyama S., Nakayama K., Nakayama KI.
Mammalian E4 is required for cardiac development and maintenance of the nervous system.
Mol. Cell. Biol., 25: 10953-64, 2005.

Yogosawa S., Hatakeyama S., Nakayama KI., Miyoshi H., Kohsaka S., Akazawa C.
Ubiquitylation and degradation of polo-like kinase SNK by hVPS18, a RING-H2 type ubiquitin ligase.
J. Biol. Chem., 280: 41619-27, 2005.

Nakayama KI., Nakayama K.
Regulation of the cell cycle by SCF-type ubiquitin ligases.
Semin. Cell. Dev. Biol., 16: 323-33, 2005.

Nakayama K., Nagahama H., Minamishima YA., Miyake S., Ishida N., Hatakeyama S., Kitagawa M., Iemura S., Natsume T., Nakayama KI.
Skp2-mediated degradation of p27 regulates progression into mitosis.
Dev. Cell, 6: 661-72, 2004.

Kamura T., Hara T., Matsumoto M., Ishida N., Okumura F., Hatakeyama S., Yoshida M., Nakayama K., Nakayama KI.
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.
Nature Cell Biol., 6: 1229-35, 2004.

Yoshida K., Nakayama K., Kase S., Nagahama H., Harada T., Ikeda H., Harada C., Imaki J., Ohgami K., Shiratori K., Ohno S., Nishi S., Nakayama KI.
Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body.
Anat. Embryol., 208: 145-50, 2004.

Uchida D., Hatakeyama S., Matsushima A., Han H., Ishido S., Hotta H., Kudoh J., Shimizu N., Doucas V., Nakayama KI., Kuroda N., Matsumoto M.
AIRE Functions As an E3 Ubiquitin Ligase.
J. Exp. Med., 199: 167-72, 2004.

Tsunematsu R., Nakayama K., Oike Y., Nishiyama M., Ishida N., Hatakeyama S., Bessho Y., Kageyama R., Suda T., Nakayama KI.
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
J. Biol. Chem., 279: 9417-23, 2004.

Matsumoto M., Yada M., Hatakeyama S., Ishimoto H., Tanimura T., Tsuji S., Kakizuka A., Kitagawa M., Nakayama KI.
Molecular clearance of ataxin-3 is regulated by a mammalian E4.
EMBO J., 23: 659-69, 2004.

Yoshida K., Kase S., Nakayama K., Nagahama H., Harada T., Ikeda H., Harada C., Imaki J., Ohgami K., Shiratori K., Ilieva IB., Ohno S., Nishi S., Nakayama KI. Yoshida K., Kase S., Nakayama K., Nagahama H., Harada T., Ikeda H., Harada C., Imaki J., Ohgami K., Shiratori K., Ilieva IB., Ohno S., Nishi S., Nakayama KI.
Involvement of p27(KIP1) in the proliferation of the developing corneal endothelium.
Invest. Ophthalmol. Vis. Sci., 45: 2163-2167, 2004.

Yoshida K., Kase S., Nakayama K., Nagahama H., Harada T., Ikeda H., Harada C., Imaki J., Ohgami K., Shiratori K., Ohno S., Nakayama KI.
Distribution of p27(KIP1), cyclin D1 and proliferating cell nuclear antigen after retinal detachment.
Graefes Arch. Clin. Exp. Ophthalmol., 242: 437-41, 2004.

Ohtsuka T., Ryu H., Minamishima YA., Macip S., Sagara J., Nakayama KI., Aaronson SA., Lee SW.
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway.
Nature Cell Biol., 6: 121-8, 2004.

Oh KJ., Kalinina A., Wang J., Nakayama K., Nakayama KI., Bagchi S.
The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin1/Skp2 containing E3 ligase.
J. Virol., 78: 5338-46, 2004.

Urushitani M., Kurisu J., Tateno M., Hatakeyama S., Nakayama KI., Kato S., Takahashi R.
CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70.
J. Neurochem., 90: 231-44, 2004.

Hatakeyama S., Matsumoto M., Yada M., Nakayama KI.
Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones.
Genes Cells, 9: 533-48, 2004.

Yada M., Hatakeyama S., Kamura T., Nishiyama M., Tsunematsu R., Imaki H., Ishida N., Okumura F., Nakayama K., Nakayama KI.
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
EMBO J., 23: 2116-25, 2004.

Li B., Wang X., Rasheed N., Hu Y., Boast S., Ishii T., Nakayama K., Nakayama KI., Goff SP.
Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase Cδ.
Genes Dev., 18: 1824-37, 2004.

Komatsu T., Mizusaki H., Mukai T., Ogawa H., Baba D., Shirakawa M., Hatakeyama S, Nakayama KI., Yamamoto H., Kikuchi A., Morohashi K.
SUMO-1 modification of the synergy control motif of Ad4BP/SF-1 regulates synergistic transcription between Ad4BP/SF-1 and Sox9.
Mol. Endocrinol., 18: 2451-62, 2004.

Akiyoshi H., Hatakeyama S., Pitkanen J., Mouri Y., Doucas V., Kudoh J., Tsurugaya K., Uchida D., Matsushima A., Oshikawa K., Nakayama KI., Shimizu N., Peterson P., Matsumoto M.
Subcellular expression of autoimmune regulator (AIRE) is organized in a spatiotemporal manner.
J. Biol. Chem., 279: 33984-91, 2004.

Terunuma M., Kanematsu T., Sang HH., Il-Sung J., Jasmina NJ., Nakayama KI., Akaike N., Sung HR., Stephen JM., Hirata M.
GABAA receptor phospho-dependent modulation is regulated by PRIP-1, a novel protein phosphatase 1 anchoring protein.
J. Neurosci., 11: 7074-84, 2004.

Nishiyama M., Nakayama K., Tsunematsu R., Tsukiyama T., Kikuchi A., Nakayama KI.
Early embryonic death in mice lacking the beta-catenin-binding protein Duplin.
Mol. Cell. Biol., 24: 8386-94, 2004.

Kamezaki K., Shimoda K., Numata A., Matsuda T., Nakayama KI., Harada M.
The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals.
Int. Immunol., 16: 1173-9, 2004.

Tokarz SA., Berset C., La Rue JM., Friedman K., Nakayama KI., Nakayama K., Zhang DE., Lanker S.
The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCF(Skp2) ubiquitin ligase.
J. Biol. Chem., 279: 46424-30, 2004.

Tamamori-Adachi M., Hayashida K., Nobori K., Omizu C., Yamada K., Sakamoto N., Kamura T., Fukuda K., Ogawa S., Nakayama KI., Kitajima S.
Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4: Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation.
J. Biol. Chem., 279: 50429-36, 2004.

Yamaguchi T., Kubota T., Kanematsu T., Nakayama KI., Hirata M., Yamamoto T.
Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1.
Brain Res., 1025: 237-40, 2004.

Okumura F., Hatakeyama S., Matsumoto M., Kamura T., Nakayama KI.
Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.
J. Biol. Chem., 279: 53533-43, 2004.

Hatakeyama S., Matsumoto M., Kamura T., Murayama M., Chui DH., Planel E., Takahashi R. Nakayama KI., Takashima A.
U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy.
J. Neurochem., 91: 299-307, 2004.

Kamura T., Maenaka K., Kotoshiba S., Matsumoto M., Kohda D., Conaway RC., Conaway JW., Nakayama KI.
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
Genes Dev., 18: 3055-65, 2004.

Blaschke F., Leppaenen O., Takata Y., Caglayan E., Liu J., Fishbein MC., Kappert K., Nakayama KI., Fleck E., Hsueh WA., Law RE., Bruemmer D.
Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries.
Circ. Res., 95: e110-23, 2004.

Mao JH., Perez-losada J., Wu D., DelRosario R., Tsunematsu R., Nakayama KI., Brown K., Bryson S., Balmain A.
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.
Nature, 432: 775-9, 2004.

Mirza AM., Gysin S., Malek N, Nakayama KI., Roberts JM., McMahon M.
Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT.
Mol. Cell. Biol., 24: 10868-81, 2004.

Mori Y., Hirose K., Suzuki K., Nakajima H., Seto Y, Ikeda K., Shimoda K., Nakayama KI., Saito Y., Iwamoto I.
Tyk2 is essential for IFN-alpha-induced gene expression in mast cells.
Int. Arch. Allergy Immunol., 134: 25-2, 2004.

Shirane M, Nakayama KI.
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis.
Nature Cell Biol., 5: 28-37, 2003.

Hatakeyama S., Nakayama KI.
U-box proteins as a new family of ubiquitin ligases.
Biochem. Biophys. Res. Commun., 302: 635-45, 2003.

Kamura T., Hara T., Kotoshiba S., Yada M., Ishida N., Imaki H., Hatakeyama S., Nakayama K., Nakayama KI.
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
Proc. Natl. Acad. Sci. U.S.A., 100: 10231-6, 2003.

Seto Y., Nakajima H., Suto A., Shimoda K., Saito Y., Nakayama K.I., Iwamoto I.
Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice.
J. Immunol., 170: 1077-83, 2003.

Kaneko C., Hatakeyama S., Matsumoto M., Yada M., Nakayama K., Nakayama KI.
Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a.
Biochem. Biophys. Res. Comm., 300: 297-304, 2003.

Kitamura K., Mizuno K., Etoh A., Akita Y., Miyamoto A., Nakayama K., Ohno S.
The second phase activation of protein kinase C delta at late G1 is required for DNA synthesis in serum-induced cell cycle progression.
Genes Cells, 8: 311-24, 2003.

Oshikawa K., Matsumoto M., Yada M., Kamura T., Hatakeyama S., Nakayama KI.
Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1.
Biochem. Biophys. Res. Comm., 303: 1209-16, 2003.

Zhang YW., Nakayama K., Nakayama K., Morita I.
A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associated protein (Skp 2).
Cancer Res., 63: 1623-30, 2003.

von der Lehr N., Johansson S., Wu S., Bahram F., Castell A., Cetinkaya C., Hydbring P., Weidung I., Nakayama K., Nakayama KI., Soderberg O., Kerppola TK., Larsson LG.
The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.
Mol. Cell, 11: 1189-200, 2003.

Bornstein G., Bloom J., Sitry-Shevah D., Nakayama K., Pagano M., Hershko A.
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase.
J. Biol. Chem., 278: 25752-7, 2003.

Imaki H., Nakayama K., Delehouzee S., Handa H., Kitagawa M., Kamura T., Nakayama KI.
Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein.
Cancer Res., 63: 4607-13, 2003.

Nakayama K., Hatakeyama S., Maruyama S., Kikuchi A., Onoe K., Good RA., Nakayama KI.
Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene.
Proc. Natl. Acad. Sci. U.S.A., 100: 8752-7, 2003.

Foster JS., Fernando RI., Ishida N., Nakayama KI., Wimalasena J.
Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway.
J. Biol. Chem., 278: 41355-66, 2003.

Watahiki J., Yamaguchi T., Irie T., Takahashi K., Nakano H., Yagasaki Y., Nakayama KI., Nakayama K., Maki K. Tachikawa T.The role of p57Kip2 on mandibular growth in mice: By means of laser microdissection for hard tissues.
Orthod. Waves, 62: 201-6, 2003.

Kato K., Kamezaki K., Shimoda K., Numata A., Haro T., Aoki K., Ishikawa F., Takase K., Ariyama H., Matsuda T., Miyamoto T., Nagafuji K., Gondo H., Nakayama K., Harada M.
Intracellular signal transduction of interferon on the suppression of haematopoietic progenitor cell growth.
Br. J. Haematol., 123: 528-35, 2003.

Chang TS., Kim MJ., Ryoo K., Park J., Eom SJ., Shim J., Nakayama KI., Nakayama K., Tomita M., Takahashi K., Lee MJ., Choi EJ.
p57KIP2 modulates stress-activated signaling by inhibiting c-Jun NH2-terminal kinase/stress-activated protein Kinase.
J. Biol. Chem., 278: 48092-8, 2003.

Aoki K., Shimoda K., Oritani K., Matsuda T., Kamezaki K., Muromoto R., Numata A., Tamiya S., Haro T., Ishikawa F., Takase K., Yamamoto T., Yumioka T., Miyamoto T., Nagafuji K., Gondo H., Nagafuchi S., Nakayama K., Harada M.
Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.
Exp. Hematol., 31: 1317-22, 2003.

Tsukuba T., Okamoto K., Okamoto Y., Yanagawa M., Kohmura K., Yasuda Y., Uchi H., Nakahara T., Furue M., Nakayama K., Kadowaki T., Yamamoto K., Nakayama KI.
Association of cathepsin E deficiency with development of atopic dermatitis.
J. Biochem., 134: 893-902, 2003.

Hatakeyama S., Nakayama KI.
Ubiquitylation as a quality control system for intracellular proteins.
J. Biochem., 134: 1-8, 2003.

Miyamoto A., Nakayama K., Imaki H., Hirose S., Jiang Y., Abe M., Tsukiyama T., Nagahama H., Ohno S., Hatakeyama S., Nakayama KI.
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta.
Nature, 416: 865-9, 2002.

Ishida N., Hara T., Kamura T., Yoshida M., Nakayama K., Nakayama KI.
Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export.
J. Biol. Chem., 277: 14355-8, 2002.

Yoshida K., Nakayama K., Nagahama H., Harada T., Harada C., Imaki J., Matsuda A., Yamamoto K., Ito M., Ohno S., Nakayama K.
Involvement of p27(KIP1) degradation by Skp2 in the regulation of proliferation in response to wounding of corneal epithelium.
Invest. Ophthalmol. Vis. Sci., 43: 364-70, 2002.

Yamanaka A., Yada M., Imaki H., Koga M., Ohshima Y., Nakayama KI.
Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns of interaction with Cullins and F-box proteins.
Curr. Biol., 12: 267-75, 2002.

Ikebe C., Kominami K., Toda T., Nakayama K.
Isolation and characterization of a novel F-box protein Pof10 in fission yeast.
Biochem. Biophys. Res. Comm., 290: 1399-407, 2002.

Minamishima YA., Nakayama K., Nakayama K.
Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice.
Cancer Res., 62: 995-9, 2002.

Murillas R., Simms KS., Hatakeyama S., Weissman AM., Kuehn MR.
Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase.
J. Biol. Chem., 277: 2897-907, 2002.

Koguchi K., Nakatsuji Y., Nakayama K., Sakoda S.
Modulation of astrocyte proliferation by cyclin-dependent kinase inhibitor p27(Kip1).
Glia., 37: 93-104, 2002.

Kanematsu T., Jang IS., Yamaguchi T., Nagahama H., Yoshimura K., Hidaka K., Matsuda M., Takeuchi H., Misumi Y., Nakayama K., Yamamoto T., Akaike N., Hirata M., Nakayama KI.
Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function.
EMBO J., 21: 1004-11, 2002.

Shimoda K., Tsutsui H., Aoki K., Kato K., Matsuda T., Numata A., Takase K., Yamamoto T., Nukina H., Hoshino T., Asano Y., Gondo H., Okamura T., Okamura S., Nakayama K., Nakanishi K., Niho Y., Harada M.
Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice.
Blood, 99: 2094-9, 2002.

Nakamichi I., Hatakeyama S., Nakayama KI.
Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18.
Mol. Biol. Cell, 13: 3441-51, 2002.

Imai Y., Soda M., Hatakeyama S., Akagi T., Hashikawa T., Nakayama KI., Takahashi R.
CHIP is associated with Parkin, a gene responsible for familial Parkinson’s disease, and enhances its ubiquitin ligase activity.
Mol. Cell, 10: 55-67, 2002.

Shimoda K, Kamesaki K, Numata A, Aoki K, Matsuda T, Oritani K, Tamiya S, Kato K, Takase K, Imamura R, Yamamoto T, Miyamoto T, Nagafuji K, Gondo H, Nagafuchi S, Nakayama K, Harada M.
Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation.
J Immunol., 169: 4707-11, 2002.

Masuda TA., Inoue H., Sonoda H., Mine S., Yoshikawa Y., Nakayama K., Nakayama K., Mori M.
Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis.
Cancer Res., 62: 3819-25, 2002.

Garcia-Fernandez LF., Losada A., Alcaide V., Alvarez AM., Cuadrado A., Gonzalez L., Nakayama K., Nakayama KI., Fernandez-Sousa JM., Munoz A., Sanchez-Puelles JM.
Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta.
Oncogene, 21: 7533-44, 2002.

Tomari S., Nagahama H., Shu Y., Hoshi S., Nakayama K., Nakayama KI., Nagata M.
Glomerular differentiation in p27 and p57 double-mutant metanephroi.
Anat. Embryol., 206: 31-6, 2002.

Hatakeyama S., Yada M., Matsumoto M., Ishida N., Nakayama KI.
U box proteins as a new family of ubiquitin-protein ligases.
J. Biol. Chem., 276: 33111-20, 2001.

Hara T., Kamura T., Nakayama K., Oshikawa K., Hatakeyama S., Nakayama K.
Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway.
J. Biol. Chem., 276: 48937-43, 2001.

Nakayama KI., Hatakeyama S., Nakayama K.
Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1.
Biochem. Biophys. Res. Comm. [Review],, 282: 853-60, 2001.

Tsukiyama T., Ishida N., Shirane M., Minamishima YA., Hatakeyama S., Kitagawa M., Nakayama K., Nakayama K.
Down-regulation of p27Kip1 expression is required for development and function of T cells.
J. Immunol., 166: 304-12, 2001.

Nagahama H., Hatakeyama S., Nakayama K., Nagata M., Tomita K., Nakayama K.
Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development.
Anat. Embryol., 203: 77-87, 2001.

Sato N., Mizumoto K., Nakamura M., Maehara N., Minamishima YA., Nishio S., Nagai E., Tanaka M.
Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells.
Cancer Genet. Cytogenet., 126: 13-9, 2001.

Kamizono S., Hanada T., Yasukawa H., Minoguchi S., Kato R., Minoguchi M., Hattori K., Hatakeyama S., Yada M., Morita S., Kitamura T., Kato H., Nakayama Ki., Yoshimura A.
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.
J. Biol. Chem., 276: 12530-8, 2001.

Kamura T., Burian D., Khalili H., Schmidt SL., Sato S., Liu WJ., Conrad MN., Conaway RC., Conaway JW., Shilatifard A.
Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose.
J. Biol. Chem., 276: 16528-33, 2001.

Ageta H., Kato A., Hatakeyama S., Nakayama K., Isojima Y., Sugiyama H.
Regulation of the level of Vesl-1S/Homer-1a proteins by ubiquitin-proteasome proteolytic systems.
J. Biol. Chem., 276: 15893-7, 2001.

Morishita H., Makishima T., Kaneko C., Lee YS., Segil N., Takahashi K., Kuraoka A., Nakagawa T., Nabekura J., Nakayama K., Nakayama KI.
Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice.
Biochem. Biophys. Res. Commun., 284: 142-9, 2001.

Xiang Z., Ahmed AA., Moller C., Nakayama KI., Hatakeyama S., Nilsson G.
Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation.
J. Exp. Med., 194: 1561-70, 2001.

Kiernan RE., Emiliani S., Nakayama K., Castro A., Labbe JC., Lorca T., Nakayama Ki. K., Benkirane M.
Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome.
Mol. Cell. Biol., 21: 7956-70, 2001.

Ikeda H., Yoshimoto T., Shida N., Miyoshi I., Nakayama K., Nakayama K., Oshima M., Taketo MM.
Morphologic and molecular analysis of estrogen-induced pituitary tumorigenesis in targeted disruption of transforming growth factor-beta receptor type II and/or p27 mice.
Endocrine, 16: 55-65, 2001.

Maruyama S., Hatakeyama S., Nakayama K., Ishida N., Kawakami K., Nakayama K.
Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10.
Genomics, 78: 214-22, 2001.

Doira N., Kanematsu T., Matsuda M., Takeuchi H., Nakano H., Ito Y., Nakayama K., Nakayama KI., Hirata M.Hyperinsulinemia in PRIP-1 gene deleted mice.
Biomed. Res., 22: 157-65, 2001.